US EPA

8245718 

Journal Article 

Activity of myristica fragrans and its effect against filamentous and non-filamentous fungus 

Pooja, V; Sanwal, H; Goyal, A; Bhatnagar, S; Srivastava, AK 

2012 

1 

International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 

4 

1 

538-540 

English 

Mace which is the aril of the fruit of Myristica fragrans HOUTT. Asian Indians have traditionally treated stomach pains, dysentery, vomiting, and the symptoms of malaria with mace. It is also chewed to prevent foul breath. The present study was carried out to elucidate the anti fungal effect of 4 extracts; Hexane, Chloroform, methanolic and Ethanolic extract obtained from Mace. The extracts were concentrated and re-suspended in ethanol. Their in-vitro susceptibility test was done by disc diffusion method. MIC80 was calculated by micro broth dilution method. Results have revealed the extracts to have good activity against both the fungal strain. Methanol and Hexane extracts have been found to be most effective against the organisms tested The MIC80 was found to be the least for Methanol extract 0.237 mg/ml against Candida albicans and 0.232 mg/ml for Aspergillus niger. Phytochemical analysis of the extracts has been conducted to ascertain the active principle associated with the antifungal activity. 

Aspergillus niger; Candida albicans; Myristica fragrans