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8256143 
Journal Article 
Tectona grandis, a potential active ingredient for hair growth promotion 
Fachrunniza, Y; Srivilai, J; Wisuitiprot, V; Wisuitiprot, W; Suphrom, N; Temkitthawon, P; Waranuch, N; Ingkaninan, K 
2020 
1 
Songklanakarin Journal of Science and Technology
ISSN: 0125-3395 
Prince of Songkla University 
42 
6 
1352-1359 
English 
This study aimed to investigate the biological activities of Tectona grandis L. f. related to hair loss treatment, including steroid 5α-reductase (S5AR) inhibition, effect on Human Follicle Dermal Papilla Cells (HFDPCs), anti-testosterone activity, cytotoxicity on macrophage cells and interleukin 1 beta (IL-1β) secretion inhibition. Among the crude extracts, T. grandis leaf-hexane and ethyl acetate (EtOAc) extracts possessed potent S5AR inhibitions, with IC50 values of 31.39±3.38 µg/mL and 20.92±2.59 µg/mL, respectively. T. grandis leaf-hexane extract showed lower cytotoxicity on HFDPCs than EtOAc extract. Hexane extract at 25 µg/mL had similar anti-testosterone activity with a positive control, finasteride, and exhibited 70% inhibition of IL-1β secretion in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Meanwhile, EtOAc extract had lower anti-testosterone activity at 6.25 µg/mL and exhibited 52% IL-1β secretion inhibition at 1.5 µg/mL. This discovery suggests T. grandis leaf extracts as a new source of active ingredients for the development of hair care products. © 2020, Prince of Songkla University. All rights reserved. 
5α-reductase inhibition; Anti-testosterone; IL-1β secretion inhibition; Tectona grandis