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8256599 
Journal Article 
Chemical composition, antioxidant, anticholinesterase and anti-urease activities of Sideritis pisidica Boiss. Heldr. endemic to Turkey 
Tel-Çayan, G; Yildirim, H; Duru, ME; Deveci, E; , 
2017 
Marmara University 
21 
4 
898-905 
English 
The objective of this study was to investigate the chemical composition, antioxidant, anticholinesterase and anti-urease activities of essential oil, hexane, acetone and methanol extracts of Sideritis pisidica Boiss. & Heldr. The essential oil and fatty acid composition were analyzed by GC and GC/MS. δ-Cadinene (19.5 %), T-cadinol (16.7 %) and β-cubebene (10.4 %) were identified as the main compounds of the essential oil whereas the most abundant compounds of fatty acids were found as linolenic (42.7 %), palmitic (31.3 %) and linoleic (13.4%) acids. The methanol extract demonstrated the highest antioxidant activity in all tests, except for metal chelating assay. The hexane extract was found to be significantly active in metal chelating (IC50: 22.97±1.36 μg/mL), acetylcholinesterase (62.54±0.88 %) and urease inhibitory (78.93±0.17 %) assays. These results show that the Sideritis pisidica could be used as the potential source of natural products in the food and pharmaceutical areas. © 2017, Marmara University. All rights reserved. 
Anti-urease activity; Anticholinesterase activity; Antioxidant activity; Essential oil; Fatty acid; Sideritis pisidica