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HERO ID
8258017
Reference Type
Journal Article
Title
Controlled biodegradability of polymers - a key to drug delivery systems
Author(s)
Kopeček, J
Year
1984
Is Peer Reviewed?
Yes
Journal
Biomaterials
ISSN:
0142-9612
EISSN:
1878-5905
Volume
5
Issue
1
Page Numbers
19-25
Language
English
DOI
10.1016/0142-9612(84)90062-0
Abstract
By combining oligopeptide sequences with synthetic polymeric chains, carriers of drug models can be prepared. The drug model (p-nitroaniline) is cleaved from the carrier in the lysosomal compartment of the cell. By changing the length and structure of the oligopeptide sequence, it is possible to regulate the rate of cleavage of drug model by individual thiol proteinases (cathepsins B, H and L) which are the most important as regards cleavage of the substrates studied. By connecting synthetic polymeric chains via oligopeptide bridges, it is possible to regulate the molecular weight as well as the biodegradability of the carrier molecule. Molecular weight also influences other biological properties e.g., elimination from the organism, rate of pinocytic uptake and biological activity. Homopolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) is nonimmunogenic in rats. Attachment of oligopeptide side chains gives rise to a macromolecule possessing immunogenic activity. The degree of antibody response depends on the detailed structure of the copolymer. © 1984.
Keywords
biodegradability; Drug carrier; lysosomal hydrolysis; N-(2hydroxypropyl) methacrylamide copolymers
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