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8260450 
Journal Article 
The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking 
Bossert, JM; Busch, RF; Gray, SM 
2005 
1 
NeuroReport
ISSN: 0959-4965
EISSN: 1473-558X 
16 
9 
1013-1016 
English 
In humans, drug-associated stimuli can provoke heroin relapse during abstinence. In rats, cues paired with heroin self-administration reinstate heroin seeking in a relapse model. The neurobiological mechanisms involved in this reinstatement, however, are largely unknown. Here, we determined the effect of LY379268, an mGluR2/3 agonist that decreases evoked glutamate release, on cue-induced reinstatement of heroin seeking. Systemic injections of LY379268 attenuated reinstatement of heroin seeking induced by exposure to a discrete tone-light cue that was previously paired with heroin infusions during self-administration training. In contrast, LY379268 had no effect on heroin self-administration. Results indicate that glutamate plays an important role in cue-induced reinstatement of heroin seeking and suggest that mGluR2/3 agonists should be considered for the treatment of opiate relapse. © 2005 Lippincott Williams & Wilkins. 
Drug cues; Metabotropic glutamate receptors; Opiate self-administration; Reinstatement; Relapse