Health & Environmental Research Online (HERO)


Print Feedback Export to File
8265866 
Journal Article 
Burn wound healing activity of hydrolyzed virgin coconut oil 
Silalahi, J; Surbakti, C 
2015 
Sphinx Knowledge House 
8 
1 
67-73 
English 
Virgin coconut oil (VCO) contains mainly medium chain fatty acids especially lauric acid, easily absorbed, has the potential to accelerate cell metabolism, moisten wound and has anti-inflammatory activity. Partial hydrolysis of VCO would result in free fatty acids, monoglycerides, and diglycerides. Combination of free fatty acids and monoglycerides especially lauric acid and monolaurin are active as antibacterial. The aim of this study was to investigate the effect of healing properties of partially hydrolyzed VCO on burn wound. VCO used in this study was the product of UD Sinar Nias. VCO was partially hydrolyzed with NaOH solution at the amount of 35% and 70% of the total saponification value. Hydrolysate was acidified with dilute HCl and then extracted with hexane. Hexane extract was evaporated and the evaporated residue was used topically for the treatment of burn induced in rabbits. This study used 10 rabbits (1.5-2 kg) divided in to five treatment groups (negative control, positive control with Bioplacenton®, VCO 0%, 35% hydrolyzed VCO and 70% hydrolyzed VCO). Burn induced by placing a hot metal plate with diameter of 2 cm. Hydrolyzed VCO as tested material was applied topically to the wound every day as much as 0.1 ml. Lesion diameter was measured every day, and the time recorded until the diameter of the healed wound was zero. The results showed that the healing process was the fastest when treated with hydrolyzed VCO at 70% (12 days), followed by VCO hydrolysis at 35% (15.5 days), VCO 0% (17.3 days), Bioplacenton ® (18.1 days) and the longest time of healing was with untreated/negative control (23.5 days). There was significant difference on the rate of healing of burn wound between each treatment. However, there is no significant difference between the positive control group (Bioplacenton®) and VCO 0% (without hydrolysis). The higher the level of hydrolysis of VCO the more effective the healing process of burn wound. © 2015, Sphinx Knowledge House. All rights reserved. 
Burn; Healing activity; Hydrolysis; Virgin coconut oil