Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8270555

Reference Type

Journal Article

Title

Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes

Author(s)

Upadhyay, S; Mantha, AK; Dhiman, M; ,

Year

2020

Is Peer Reviewed?

Yes

Journal

Journal of Ethnopharmacology
ISSN: 0378-8741

Publisher

ELSEVIER IRELAND LTD

Location

CLARE

Volume

258

Page Numbers

112690

Language

English

PMID

32105749

DOI

10.1016/j.jep.2020.112690

Web of Science Id

WOS:000536887800015

URL

https://linkinghub.elsevier.com/retrieve/pii/S0378874119340553
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Abstract

Doxorubicin (DOX) is an effective anti-neoplastic drug, however; it has downside effects on cardiac health and other vital organs. The herbal remedies used in day to day life may have a beneficial effect without disturbing the health of the vital organs. Glycyrrhiza glabra L. is a ligneous perennial shrub belonging to Leguminosae/Fabaceae/Papilionaceae family growing in Mediterranean region and Asia and widespread in Turkey, Italy, Spain, Russia, Syria, Iran, China, India and Israel. Commonly known as mulaithi in north India, G. glabra has glycyrrhizin, glycyrrhetic acid, isoliquiritin, isoflavones, etc., which have been reported for several pharmacological activities such as anti-demulcent, anti-ulcer, anti-cancer, anti-inflammatory and anti-diabetic.