Cerebroprotective effect of combined treatment with pyrazidol and bemitil in craniocerebral trauma | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

8271763

Reference Type

Journal Article

Title

Cerebroprotective effect of combined treatment with pyrazidol and bemitil in craniocerebral trauma

Author(s)

Zarubina, IV; Kuritsyna, NA; Shabanov, PD; ,

Year

2004

Is Peer Reviewed?

Yes

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888
EISSN: 1573-8221

Publisher

CONSULTANTS BUREAU

Location

NEW YORK

Page Numbers

58-62

Language

English

PMID

15514724

DOI

10.1023/b:bebm.0000046939.59393.ac

Web of Science Id

WOS:000226087500018

URL

http://link.springer.com/10.1023/B:BEBM.0000046939.59393.ac
Exit

Abstract

Monotherapy of consequences of craniocerebral trauma with pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemitil in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemitil was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemitil had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.