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8280936 
Journal Article 
In vivo and in vitro anti-inflammatory activity of semi-synthetic derivatives of isolated solanesol from tobacco scrap 
Sridevi, P; Bhagavan Raju, M; Harikumar Verma, V; Rangarao, P; Rajareddy, R; Rekha, V; Singh, N 
2015 
Global Research Online 
31 
2 
210-217 
English 
Solanesol is a terpene isolated from tobacco waste and it is an important intermediate of nutrients such as vitamin K2 and coenzyme Q10. Researchers are examining the potential for producing vaccines and other high-value protein products from genetically engineered tobacco. In addition to these compounds, there are several additional products found in tobacco that might add to the overall revenue stream. Solanesol is one of them, which constitutes a portion of the Co-enzyme Q10 molecule; sucrose esters, natural insecticides and found on the leaf surface of certain Nicotiana species. The new method was prepared for the extraction of pure solanesol by a safe, economic, ecofriendly and industrial viable process. Similarly ten semi synthetic derivatives of solanesol were prepared with acceptable degree of purity, and their structures were elucidated with the help of IR, MASS, NMR (spectral data). In vitro and in vivo anti inflammatory activity showed that few semi-synthetic compounds showed improved anti inflammatory activity than solanesol. Comparison between in vitro and in vivo activity showed that PA1, MA1 and MA2 derivatives showed improved activity that the parent compound Solanesol. © 2015, Global Research Online. All rights reserved. 
Anti-inflammatory; Solanesol; Vitamin K2 and coenzyme Q10