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8289277 
Journal Article 
High Concentration of Glial Cell Line-Derived Neurotrophic Factor Protects Primary Astrocytes from Apoptosis 
Wang, Y; Qin, Y; Guo, T; Tang, C; Liu, L; Gao, D; , 
2018 
Yes 
Developmental Neuroscience
ISSN: 0378-5866
EISSN: 1421-9859 
KARGER 
BASEL 
134-144 
English 
29656289 
WOS:000435486800004 
Studies have shown that astrocytes play an important role in a variety of biological processes, so damage to astrocytes can cause a series of related diseases. Glial cell line-derived neurotrophic factor (GDNF) has always been considered a protective factor for dopamine neurons. However, it remains unclear whether GDNF has a protective effect on glial cells, especially astrocytes. In this study, we put forward the hypothesis that a high concentration of GDNF in the microenvironment of astrocytes exerts an inhibitory effect on the apoptosis of astrocytes by DNA-damaging reagents.