US EPA

8292505 

Journal Article 

Alterations of immune reactivity by haloperidol and delta-9-tetrahydrocannabinol 

Levy, JA; Heppner, GH 

1981 

Yes 

Immunopharmacology and Immunotoxicology
ISSN: 0892-3973
EISSN: 1532-2513 

3 

1 

93-109 

English 

10.3109/08923978109026421 

Studies were performed to determine whether Δ9-tetrahydrocannabinol (THC) or haloperidol suppress or ablate humoral or cellular immune responses against sheep erythrocytes. Both agents produced dose-dependent reductions in henolytic plaque-forming cell (PFC) numbers at the time of peak reactivity (Day 4) in vehicle-treated, control mice. However, both Δ9-THC and haloperidol only delayed the time of peak PFC formation by 24-48 hours. These changes in kinetics of humoral immune responsiveness took place at doses of Δ9-THC and haloperidol that produced signs of gross behavioral toxicity. Neither Delta-9-THC, cannabinol (CBN) or cannabidiol (CBD) had an effect on the titer of serum hemagglutinat-ing antibody measured seven days after immunization. Further, haloperidol did not alter the delayed-type hypersensitivity response to dinitroflorobenzene (DNFB). © 1981 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.