US EPA

8306159 

Journal Article 

Chemopreventive action of syzygium cumini seed extract on benzopyrene-induced gastric cancer 

Verma, P; Agrawal, A; Sharma, P; Parmar, J; Sharma, P; Goyal, PK 

2010 

2 

995-1007 

English 

The chemopreventive effect hydro alcoholic extract of Syzygium cummini extract (SCE) at a dose 125 mg/kg b.wt. was studied on the benzo(a)pyrene (BaP) induced fore stomach carcinoma in male mice. Syzygium cummini was used to explore antitumor promoting activity in a one-stage stomach carcinogenesis model. For this purpose, mice were administered with 1 mg of Bap in 100 μl sesame oil by oral gavage twice a week for 4 consecutive weeks and the animals were sacrificed 14 weeks after the last administration of BaP. Oral administration of the above extract in the Pre-post treated Group (i.e. such animals received the dose of SCE for 2 weeks before treatment with BaP followed by the concomitant treatment with SCE & BaP for 4 weeks during and 2 weeks after the last administration of BaP), recorded a significant reduction in tumor incidence, tumor burden, cumulative number of papillomas along with a significant elevation of phase II detoxifying enzymes, and inhibition of lipid per oxidation in the stomach of the animals. The present data strongly suggests that the Syzygium cummini extract has anti-tumor potential against chemical induced gastric carcinogenesis. 

Antioxidants; Carcinogen; Chemoprevention; Phase ii enzymes; Stomach papillomas; Syzygium cummini