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8306212 
Journal Article 
Schiff bases - synthesis, characterization and antibacterial activity 
Baluja, S; Patel, A; Chanda, S 
2011 
0 
Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585 
2 
4 
296-304 
English 
Six Schiff bases viz. (1) 4-[1-aza-2- (2-chlorophenyl) vinyl]-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [SS1] (2) 4-[1-aza-2- (2-hydroxyphenyl) vinyl]-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [SS2] (3) 4-[1-aza-4-phenylbuta-1, 3-dienyl] 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [SS3] (4) 4-[2-aza-2- (2-chlorophenyl) vinyl] benzene sulfonamide [SS4] (5) 4-[2-aza-2- (2-hydroxyphenyl) vinyl] benzene sulfonamide [SS5] (6) [1-aza-4-phenylbuta-1, 3-dienyl] benzene sulfonamide [SS6] synthesized from sulphanilamide and 4- aminoantipyrene were characterized by IR and NMR spectral analysis. The antibacterial activity was studied against P. pseudoalcaligenes ATCC 17440, P. vulgaris NCTC 8313, C. freundii ATCC 10787, E. aerogenes ATCC 13048, S. subfava NCIM 2178 and B. megaterium ATCC 9885. The antibacterial activity was evaluated using Agar Ditch method. Two polar solvents were used viz Dimethyl formamide (DMF) and Dimethyl sulfoxide (DMSO). A differential effect of the compounds was found in the bacterial strains investigated and the solvents used, again suggesting that the antibacterial activity is dependent on the molecular structure of the compound, solvent used and the bacterial strains under consideration. In the present work, sulphanilamide as the central ligand and solvent DMF appears to be the best in inhibiting the studied clinically important bacterial strains. 
Antibacterial activity; Drug designing; Polar solvents; Schiff bases