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8306287 
Journal Article 
Generation of uniformly sized alginate microparticles for cell encapsulation by using a soft-lithography approach 
Qiu, C; Chen, M; Yan, H; Wu, H 
2007 
Yes 
Advanced Materials
ISSN: 0935-9648
EISSN: 1521-4095 
WILEY-V C H VERLAG GMBH 
WEINHEIM 
19 
12 
1603-1607 
English 
WOS:000247761800009 
A different strategy for the generation of uniformly sized alginate gel particles polydimethylsiloxane (PDMS) with sizes in the range 10-500 μm using soft lithography was reported. The hydrophobic nature of PDMS can cause bubbles to be trapped in the microwells when applying the aqueous solutions. After the microwells are completely filled, the PDMS template was tilted so that each well is at an angle of about 45 degrees to the horizontal. To demonstrate the capabilities of this technique for the production of uniformly sized gel microparticles, patterns of different microwells were used to form gel particles with various shapes and dimensions. It was observed that freestanding alginate gel microparticles can be released from the PDMS microwells by stretching the elastomeric PDMS template or swelling the PDMS template with hexane.