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8306865 
Journal Article 
Review 
Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases 
Haskã³, G; Linden, J; Cronstein, B; Pacher, P 
2008 
1 
Nature Reviews. Drug Discovery
ISSN: 1474-1776
EISSN: 1474-1784 
NATURE PUBLISHING GROUP 
LONDON 
7 
9 
759-770 
English 
18758473 
WOS:000258915800018 
Adenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system express these receptors and are responsive to the modulatory effects of adenosine in an inflammatory environment. Animal models of asthma, ischaemia, arthritis, sepsis, inflammatory bowel disease and wound healing have helped to elucidate the regulatory roles of the various adenosine receptors in dictating the development and progression of disease. This recent heightened awareness of the role of adenosine in the control of immune and inflammatory systems has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.