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8307413 
Journal Article 
Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry 
Chowdhury, G; Guengerich, FP 
2008 
Yes 
Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773 
WILEY-V C H VERLAG GMBH 
WEINHEIM 
47 
2 
381-384 
English 
18022988 
WOS:000252270100027 
(Graph Presented) Map reading: Alkylation of a 15-base-pair double-stranded oligonucleotide modified with the carcinogen (±)-anti-benzo[a]pyrene diol epoxide (see picture) or N-hydroxy-4-aminobiphenyl is mapped by liquid chromatograhy-tandem mass spectrometry and collision-induced dissociation (CID). The method does not require prior DNA cleavage or hydrolysis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA. 
Alkylation; Collision-induced dissociation; DNA damage; Mass spectrometry; Oligonucleotides