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8308080 
Journal Article 
Development of stability indicating HPTLC method for simultaneous estimation of paracetamol and dexibuprofen 
Chitlange, SS; Soni, R 
2010 
3 
1 
1-4 
English 
The present work describes a stability-indicating HPTLC method for analysis of paracetamol and dexibuprofen in bulk and pharmaceutical dosage form. Precoated silica gel 60 F254 plate was used as stationary phase. The separation was carried out using n-hexane: ethyl acetate: glacial acetic acid (5: 5: 0.2 %v/v/v) as mobile phase. The densitometric scanning was carried out at 223 nm. The linearity was obtained in the range 10-50 μg/band for paracetamol and 6-30 μg/band for dexibuprofen with correlation coefficients (r2) 0.9915 and 0.9969 for paracetamol and dexibuprofen respectively. The method was validated as per ICH guidelines. The combination was subjected to forced degradation by acid, alkali, oxidation and dry heat. The degradation products were well resolved from the pure drug with significantly different Rf values. 
Dexibuprofen; HPTLC; Paracetamol; Stability studies; Validation