Health & Environmental Research Online (HERO)


Print Feedback Export to File
8309757 
Journal Article 
High protein diet induced hepatic oxidative stress and its amelioration by the herb, Emilia sonchifolia (L.)DC 
Sophia, D; Ragavendran, P; Arul Raj, C; Gopalakrishnan, VK 
2011 
1 
149-154 
English 
Diet should be consistent with balanced composition to maintain healthy life. Unbalanced diet can cause serious adverse effects to the mankind including oxidative stress. The aim of this study is to investigate the protective effect of the medicinal herb, Emilia sonchifolia against the high protein diet induced oxidative stress. Twenty four male wistar rats randomly divided into 4 groups (n = 6 each) were taken. Group 1 (normal diet: standard pellets), Group II (high protein diet: 100% Raw Soya Flour), Group III (100% Raw Soya Flour with oral administration of 250 mg/kg b. wt. of nhexane extract of Emilia sonchifolia), Group IV- n-hexane extract of Emilia sonchifolia alone. (250 mg/kg b.wt). The animals were sacrificed after the experimental period of 1 month. Significant (p< 0.05) increase in lipid peroxidation and decrease in antioxidant enzymes were seen in GroupI rats. Treatment with n-hexane extract of Emilia sonchifolia (250 mg/kg) significantly (p<0.05) prevented the increase in lipid peroxidation whereas SOD, CAT, GPx, GST GSH and vitamin C were significantly (p< 0.05) increased in Group III animals. This was evident from the histopathological studies. Thus the findings suggest that Emilia sonchifolia is a potential therapeutic agent. 
Antioxidants; Emilia sonchifolia; High protein diet; Oxidative stress