US EPA

8310000 

Journal Article 

Antidiabetic and wound healing activity of various bark extracts of Polyalthia longifolia 

Lakshmi, A; Rao, YM; Bhargavi, CH; Seelam, U 

2011 

4 

1 

109-113 

English 

Aim: The present study was sought to investigate the antidiabetic and wound healing activity of bark extract of Polyalthia longifolia against alloxan induced diabetic rats. Method: The antidiabetic activity is evaluated by estimating the blood glucose level, total protein, total cholesterol, creatinine and blood urea and nitrogen in alloxan induced diabetic rats. The wound healing activity property was studied by excision and incision methods. Results: There is a significant decrease in the blood glucose levels from 1 week to 3 week in n-hexane extract, ethyl acetate and methanolic extract treated groups when compared to the diabetic control group. The n-hexane extract treated group has shown significant increase in the total cholesterol, creatinine and urea levels when compared to the other treated groups and is almost similar to the standard group. In contrast the methanolic extract has brought has brought the total protein level to the normal in diabetic induced rats. Conclusion: In conclusion the present study indicated a significant antidiabetic effect of the methanolic extract of Polyalthia longifolia and supports its traditional usage in the control of diabetes. It was found to have strong wound healing property. Further studies are required for the detailed studies in isolation of the compounds and pharmacological investigations of the bark constituents, which possess its own traditional claim. 

Antidiabetic; Polyalthia longifolia; Wound healing