US EPA

8311710 

Journal Article 

Antidiabetic activity of different extracts of Dalbergia sissoo DC. stem bark on streptozotocin-nicotinamide induced type 2 diabetic rats 

Saini, S; Sharma, S 

2013 

1 

International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 

5 

4 

228-235 

English 

Objective: To investigate the antidiabetic potential of alcoholic and aqueous stem bark extract of Dalbergia sissoo DC. and their fractions on streptozotocin-nicotinamide induced type 2 diabetic rats. Methods: Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water (2g/kg). Single dose of different extracts of Dalbergia sissoo DC. was administered to normoglycemic and hyperglycemic rats. Type2 diabetes was induced by single intraperitoneal injection of nicotinamide (110mg/kg) followed by streptozotocin (65mg/kg). The study includes estimations of blood glucose levels, lipid profile, liver glycogen, body weight and antioxidant status in normal and diabetic rats. Results: Studies showed that alchohalic extracts (250 and 500mg/kg respectively) and aqueous extract (400mg/kg) significantly reduced the blood glucose level (P<0.05) where as hexane soluble extract and butane soluble extract did not reduced the blood glucose level significantly (P>0.05) when compared with glibenclamide. Alcoholic extracts and aqueous extracts significantly restored the lipid profile and showed improvement in liver glycogen, body weight and antioxidant status in diabetic rats. Conclusion: Present findings demonstrated the significant antidiabetic activity of alcoholic and aqueous bark extract of Dalbergia sissoo DC. Chlorogenic acid and polyphenols present in seeds is reported to have antidiabetic effect. 

Antidiabetic; Dalbergia sissoo DC.; Oral glucose tolerance test; Streptozotocin; Streptozotocin induced diabetes