The methanolic and hexane extracts of Musa acuminate peel (Plantain peel) were pharmacologically validated for immunomodulatory activity at dose (100, 300, 500mg/kg b.wt., p.o.) by carbon clearance method, neutrophil adhesion and footpad swelling method on Wistar albino rats. Results of present studies suggested that both hexane and methanolic extracts of Musa acuminate was found to be potent immuo-stimulant in a dose dependent manner when compared with control group. Though, the results were more pronounced in methanolic extract. ©IDOSI Publications, 2013.