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8315710 
Journal Article 
Sarcolipin protein interaction with Sarco(endo)plasmic reticulum CA 2+ ATPase (SERCA) Is distinct from phospholamban protein,and only sarcolipin can promote uncoupling of the serca pump 
Sahoo, SK; Shaikh, SA; Sopariwala, DH; Bal, NC; Periasamy, M 
2013 
Yes 
Journal of Biological Chemistry
ISSN: 0021-9258
EISSN: 1083-351X 
288 
10 
6881-6889 
English 
23341466 
Background: Sarcolipin and phospholamban, the regulators of SERCA, are differentially expressed in muscle. Results: Only sarcolipin binds to SERCA in the presence of Ca2α and interacts with SERCA throughout the kinetic cycle. Conclusion: Sarcolipin alone promotes uncoupling of the SERCA pump leading to increased heat production. Significance: Sarcolipin-mediated regulation of SERCA plays an important role in muscle-based thermogenesis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.