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Citation
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HERO ID
8318211
Reference Type
Journal Article
Title
A neurogenetics approach to defining differential susceptibility to institutional care
Author(s)
Brett, ZH; Sheridan, M; Humphreys, K; Smyke, A; Gleason, MM; Fox, N; Zeanah, C; Nelson, C; Drury, S; ,
Year
2015
Volume
39
Issue
2
Page Numbers
150-160
Language
English
PMID
25663728
DOI
10.1177/0165025414538557
URL
http:///dx.doi.org/10.1177/0165025414538557
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Abstract
An individual's neurodevelopmental and cognitive sequelae to negative early experiences may, in part, be explained by genetic susceptibility. We examined whether extreme differences in the early caregiving environment, defined as exposure to severe psychosocial deprivation associated with institutional care compared to normative rearing, interacted with a biologically informed genoset comprising BDNF (rs6265), COMT (rs4680), and SIRT1 (rs3758391) to predict distinct outcomes of neurodevelopment at age 8 (N = 193, 97 males and 96 females). Ethnicity was categorized as Romanian (71%), Roma (21%), unknown (7%), or other (1%). We identified a significant interaction between early caregiving environment (i.e., institutionalized versus never institutionalized children) and the a priori defined genoset for full-scale IQ, two spatial working memory tasks, and prefrontal cortex gray matter volume. Model validation was performed using a bootstrap resampling procedure. Although we hypothesized that the effect of this genoset would operate in a manner consistent with differential susceptibility, our results demonstrate a complex interaction where vantage susceptibility, diathesis stress, and differential susceptibility are implicated.
Keywords
Genetics; Institutionalized Persons; Residential Care; Cognitive Processes; Caregivers; Environment; Intelligence Quotient; Spatial Ability; Short Term Memory; Sampling; Statistical Inference; Validity; Neurological Organization; Demography; Infants; Diagnostic Tests; Foreign Countries; Wechsler Intelligence Scale for Children; Romania; Romania; Wechsler Intelligence Scale for Children
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