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8320818 
Journal Article 
Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells 
Hosokawa, J; Suzuki, K; Nakagomi, D; Tamachi, T; Takatori, H; Suto, A; Nakajima, H; , 
2013 
Yes 
International Archives of Allergy and Immunology
ISSN: 1018-2438
EISSN: 1423-0097 
KARGER 
BASEL 
37-43 
English 
23711852 
WOS:000319504900007 
Mast cells are known to play a pivotal role in allergic diseases by releasing granules containing histamine and other preformed chemical mediators. Cross-linking of high-affinity receptors for IgE (FcεRI) on mast cells results in rapid increases in intracellular free calcium concentration [Ca(2+)]i and consequent activation of many transcription factors, including NFAT, NF-κB, JNK and CREB. Ca(2+) signaling is essential for many cellular activities such as proliferation, gene expression and degranulation in mast cells. In addition to Ca(2+) signaling, previous reports have shown that IkappaB kinase 2 (IKK2 or IKKβ), a central component of the IKK complex mediating NF-κB activation, also plays a crucial role in FcεRI-mediated degranulation and cytokine production. Moreover, it has been demonstrated that activation of PKCβ, a calcium-dependent PKC isoform, leads to IKK2 activation in many cell types. However, the roles of Ca(2+) signaling and PKCβ in the activation of IKK2 in mast cells remain largely unknown.