Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8321973

Reference Type

Journal Article

Title

Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients

Author(s)

Petersen, M; Andersen, JT; Hjelvang, BR; Broedbaek, K; Afzal, S; Nyegaard, M; Børglum, AD; Stender, S; Køber, L; Torp-Pedersen, C; Poulsen, HE; ,

Year

2011

Is Peer Reviewed?

Yes

Journal

British Journal of Clinical Pharmacology
ISSN: 0306-5251
EISSN: 1365-2125

Publisher

WILEY

Location

HOBOKEN

Page Numbers

556-565

Language

English

PMID

21395649

DOI

10.1111/j.1365-2125.2010.03868.x

Web of Science Id

WOS:000288249500012

URL

https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2010.03868.x
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Abstract

Pharmacogenetics can be used as a tool for stratified pharmacological therapy in cardiovascular medicine. We investigated whether a predefined combination of the Arg389Gly polymorphism in the adrenergic β(1) -receptor gene (ADRB1) and the Gln27Glu polymorphism in the adrenergic β(2) -receptor gene (ADRB2) could predict survival in carvedilol- and metoprolol-treated chronic heart failure (HF) patients.