Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
8322660
Reference Type
Journal Article
Title
Oxycodone
Author(s)
Kalso, E
Year
2005
Is Peer Reviewed?
Yes
Journal
Journal of Pain and Symptom Management
ISSN:
0885-3924
Publisher
Elsevier Inc.
Volume
29
Issue
5 SUPPL.
Page Numbers
47-56
Language
English
DOI
10.1016/j.jpainsymman.2005.01.010
Abstract
Oxycodone has been in clinical use since 1917. Parenteral oxycodone was used mainly for the treatment of acute postoperative pain whereas combinations, for example, oxycodone and acetaminophen, were used for moderate pain. Since the introduction of controlled-release oxycodone, it has been used to manage cancer-related pain and chronic non-cancer-related pain problems. Controlled studies have been performed in postoperative pain, cancer pain, osteoarthritis-related pain, and neuropathic pain due to postherpetic neuralgia and diabetic neuropathy. The pharmacodynamic effects of oxycodone are typical of a μ-opioid agonist. Oxycodone closely resembles morphine but it has some distinct differences, particularly in its pharmacokinetic profile. Being an old drug, the basic pharmacology of oxycodone has been a neglected field of research. © 2005 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
Keywords
Oxycodone; Oxymorphone
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity