Health & Environmental Research Online (HERO)


Print Feedback Export to File
8322690 
Journal Article 
The Anxiolytic Effect of the Neuropeptide Cycloprolylglycine Is Mediated by AMPA and TrkB Receptors 
Gudasheva, TA; Povarnina, PY; Koliasnikova, KN; Alyaeva, AG; Vorontsova, ON; Seredenin, SB; , 
2020 
Yes 
Doklady Biochemistry and Biophysics
ISSN: 1607-6729
EISSN: 1608-3091 
MAIK NAUKA/INTERPERIODICA/SPRINGER 
NEW YORK 
190-192 
English 
32894462 
WOS:000566732700006 
Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological effects of CPG are associated with the brain neurotrophic factor. In this paper, we have first demonstrated that DNQX, an inhibitor of AMPA receptors, and K252A, an ihibitor of Trk receptors, prevented the anxiolytic effect of CPG, which confirms the formulated hypothesis.