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8323980 
Journal Article 
Increasing the local concentration of drugs by hydrogel formation 
Tiller, JC 
2003 
Yes 
Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773 
WILEY-V C H VERLAG GMBH 
WEINHEIM 
42 
27 
3072-3075 
English 
12866093 
WOS:000184360600002 
Drugs that gel: The first hydrogel-forming drug, a pyrene-derivatized form of the antibiotic vancomycin (see structure), exhibits an 11-fold higher antimicrobial activity than vancomycin itself. A possible mechanism for this effect and its influence on future drug design are discussed. 
Antibiotics; Drug design; Gels; Hydrogelators; Vancomycin