Labu, ZK; Laboni, FR; Tarafdar, M; Howlader, MSI; Rashid, MH
Spondiasis pinanata is a medicinal herb belonging to the family of Anacardiaceae, also known as wild mango, hog-plum which has a history of ethnomedicinal properties. The crude ethanolic extract and its different partitionates of the leaves of S. Pinanata were evaluated for its possible thrombolytic and anti-inflammatory activities. The activities of the leaf extract were evaluated by using standard drugs; Streptokinase (SK), used for thrombolytic activity, and acetyl salicylic acid (ASA), for anti-inflammatory activity. In this study, SK showed 69.23%, the ethanolic soluble fraction of leaves (ESF) 43.28%, n-Hexane soluble fraction (HXSF) 58.06%, chloroform soluble fraction (CSF) 27.66% and aqueous soluble fraction (AQSF) 22.81% activity against thrombosis. For human red blood cell (HRBC) membrane stabilization, ASA and leaves extractives soluble fractionates significantly inhibits the haemolysis of HRBC membrane which was induced by hypnotic solutions, with their inhibition results of ASA(81.90±29%), AQSF (33.49±0.51%), ESF(58.23±0.64%), CSF(49.66±0.77%), HXSF(70.35±0.50%) respectively. While, ASA and leaves extractives soluble fractionates protected significantly heat-induced lysis of human red blood cell membrane, with their values of ASP being (74.12±0.26%), AQSF (30.34±0.42%), ESF (51.53±0.61%), CSF (46.22±0.57%), HXSF (61.11±0.69%) respectively. Hence, the results of the present study revealed that the traditional uses of this plant leaves is a remedy for thrombosis and unstable blood red cell membrane. © 2015, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.
