US EPA

8325841 

Journal Article 

Isolated burn skin pathogens: Screening against extract of carissa edulis vahl and computational studies 

Alodeani, EA 

2016 

0 

International Journal of Pharmacognosy and Phytochemical Research
ISSN: 0975-4873 

International Journal of Pharmacognosy and Phytochemical Research 

8 

10 

1610-1613 

English 

The extract of Carissa edulis Vahl was evaluated for the potential therapeutic effects against pathogens isolated from the skin of burn patients such as Pseudomonas aeruginosa, Staphylococcus aureus, acinetobacter baumannii, Klebsiella spp, Proteus vulgaris and Escherichia coli. The biological screening results exhibited that methanol extract has more potential therapeutic effect than n-hexane extract. Considerable zone of inhibition was observed for both the extract against S. aureus and E. coli. The computational studies were carried out for all components to calculate physicochemical parameters and drug likeness and portrayed that all components found in compliance with the Lipinski rule of five and have the bioactivity score in the category of active drugs. © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved. 

Burn skin pathogens; Carissa edulis vahl extraction; Drug likeness and physicochemical property