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8326458 
Journal Article 
Tricholoma giganteum Ameliorates Benzo[A]Pyrene - Induced Lung Cancer in Mice 
Chatterjee, S; Chatterjee, A; Chandra, S; Khatua, S; Saha, GK; Acharya, K 
2016 
Publishers 
7 
5 
283-290 
English 
Tricholoma giganteum is a wild edible mushroom, consumed in tropical region of the world and demonstrated to have multiple beneficial effects. We investigated the chemopreventive effect of ethanolic fraction of T. giganteum in mice with acute lung injury induced by Benzo[a]Pyrene. Oral administration of Benzo[a]Pyrene (1 mg/20g body weight) induced marked lung injury, evident from histological and biochemical data. Intraperitoneal administration of ethanolic fraction of T. giganteum (50 mg/kg body weight) significantly overcame the side effect of benzo[a]pyrene by modulation of different antioxidant enzyme and pro/anti-apoptotic gene ratio. Therefore, it could be inferred that alcoholic extract of T. giganteum may hold promise as a chemopreventive agent during the early phases of carcinogenesis. 
Benzo[a]pyrene; Lung cancer; Mushroom; Tricholoma giganteum; Tropical medicine