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8326561 
Journal Article 
Advances in contemporary research: Chemistry of cigarette smoking - A review 
Mitra, SP 
2016 
1 
Indian Journal of Chemistry. Section B
ISSN: 0376-4699
EISSN: 0975-0983 
Scientific Publishers 
55B 
3 
321-343 
English 
This comprehensive article illustrates the facts about cigarette smoking, dealing primarily with the underlying chemistry and biochemical features linked to tobacco related effects. A major attempt is made to discuss crucial factors concerning the chemical effects of tobacco smoke. In that regard following aspects are incorporated into the discussion: The chemical contents of original tobacco and its pyrolytic products in the smoke; The pyrolysis; The physico-chemical nature of nicotine molecule: biosynthesis, metabolism and receptor interaction; The nicotine addiction; The harmful effects of tobacco and other thermolytic chemicals on health. The detection of smoke inhalation by using suitable bio-chemical markers. Additional discussion is provided regarding the importance of pH during tobacco processing, which plays a distinctive role on nicotine absorption and influencing the addiction. The use of nicotine patch, gum or lozenges to avoid the harmful effects of smoke are also reviewed. More deliberation is offered on the action of nicotine with regard to biosynthesis, metabolism, receptor interaction and its physiologic role, considering the molecule to be an important item of tobacco, enabling to provoke addiction in the brain. The usefulness of synthetic mimicry of nicotine is also brought into light for.its preventive role on addiction as well as to treat Alzheimer's and Perkinson's or other neurological diseases. Additionally, cotinine, the major metabolite of nicotine is also momentarily reviewed in the light of similar medicinal approaches. In brief, the review describes the overall chemistry and biochemistry involved in the use of tobacco. 
4-aminobiphenyl; Alzheimer's disease; Benzene; Benzo[a]pyrene; Ca+2-channel; Cotinine; Cytochrome P450-2A6; Dopamine; Heterocyclics; LTP; Nachr; Nicotine; NRT; Parkinson's disease; Pyrolysis; Tobacco; VTA; α-napthylamine