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8326838 
Journal Article 
Influence of nitrogen source in culture media on antimicrobial activity of Microcoleus lacustris and Oscillatoria rubescens 
Sultan, YY; Ali, MA; Darwesh, OM; Embaby, MA; Marrez, DA 
2016 
0 
Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585 
Research Journal of Pharmaceutical, Biological and Chemical Sciences 
7 
2 
1444-1452 
English 
The cyanobacterial, Microcoleus lacustris and Oscillatoria rubescens were cultivated in three different media, BG-11 (NaNO3 as nitrogen source), modified BG-11 (urea as nitrogen source) and SHU (combined between urea and NH4Cl as nitrogen sources). The cyanobacterial aqueous, methanol, chloroform and hexane extracts were screened for their antimicrobial activities against four pathogenic bacterial strains (Bacillus cereus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), one yeast (Candida albicans) and two fungal strains (Aspergillus flavus and Aspergillus niger). Both methanol and hexane extracts of M. lacustris from the three media exhibited antibacterial activity against all tested bacteria. While, only methanol of M. lacustris from BG-11 medium exhibited activity against tested yeast and fungi. Also, O. rubescens methanol, chloroform and hexane extracts exhibited highest antimicrobial activity against all tested microorganisms followed by modified BG-11. Generally, highest antibacterial and antifungal activities of both M. lacustris and O. rubescens were possessed from extracts cultivated in BG-11 medium. 
Antibacterial; Antifungal; Microcoleus lacustris; Nitrogen source; Oscillatoria rubescens