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8328064 
Journal Article 
Synthesis,characterisation and antibacterial activity of some [8-amino-4,7-dihydroxy-chromen-2-one] , [N-(3-cyano-4-ethoxy-2-oxo-2h-chromen-7-yl)-formamide] derivatives. The comparison with standard drug 
Behrami, A; Vaso, K; Govori, S; Krasniqi, I; Demaku, S; Vehapi, I 
2012 
0 
Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585 
3 
2 
876-883 
English 
The present study deals with the sysnthesis , struscture and antibacterial activity of [8-Amino-4,7-dihydroxy-chromen-2-one].[N-(3-Cyano-4-ethoxy-2-oxo-2H-chro men-7-yl)-formamide].Derivatives are reported Compounds 2 - Chloro - 8- hydroxyl - 7-iminomethyl - 4H-1,5-dioxa-4-aza-phenanthrene-3,6-dione(a1).N-(4-Ethoxy-3-fo rmyl-2-oxo-2H-chromen-7-yl)-formamide(b1).4-Ethoxy-7-formylam ino-2-oxo-2H-chromene-3-carboxylic acid (2-chloro-8-hydroxy-3,6-dioxo-3,4-dihydro-2H,6H-1,5-dioxa-4-aza-phenanth ren-7-ylmethyl)-amide(c). 4-Ethoxy-7-[3 - (4-methoxy - phenyl)-ureido]-2-oxo-2H-chromene-3-carboxylic acid [2- chloro - 8 - (4- methoxy - phenylamino)-3,6 - dioxo-3,4-dihydro-2 H,6H-1,5-dioxa-4-aza-phenanthren-7-ylmethyl]-amide(d).The structures of the synthesized compounds:(a1,b1,c,d) were characterized by spectroscopic methods,(IR, H1-NMR , & C13-NMR) and analytical techniques (elemental analysis , melting point and TLC).The antibacterial activity of synthesized compounds was compared with antibacterial activity of the standard antibiotics cephalexine and streptomycine.The compounds shows different bacteriostatic and bactericidal activity against two cultures;Staphylococcus.aureus,Bacillus.cereus. 
[8-Amino-4,7-dihydroxy-chromen-2-one]; Antibacterial activity; Bacillus cereus; Cephalexine; Staphylococcusaureus