Studies on the anti-inflammatory and antiplatelet activities of constituents isolated from the roots and stems of Cassia occidentalis L | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8328300

Reference Type

Journal Article

Title

Studies on the anti-inflammatory and antiplatelet activities of constituents isolated from the roots and stems of Cassia occidentalis L

Author(s)

Kuo, SC; Chen, SC; Lo, CF; Teng, CM; Wang, JP

Year

1996

Volume

Issue

Page Numbers

291-302

Language

English

Abstract

Five known compounds - chrysophanol (1), physcion (2), emodin (3), cassiollin (4) and luteolin 5,3'-dimethyl ether (5) were isolated from the hexane and chloroform-soluble fractions of the methanolic extract of Cassia occidentalis. Among them, luteolin 5,3'-dimethyl ether was isolated for the first time from this plant. The structures of these compounds were confirmed on the basis of 2D-NMR studies, which also led to the revised assignment of the 1H NMR spectrum of cassiollin. Biological tests showed that cassiollin slightly inhibited the release of Î²-glucuronidase and lysozyme from neutrophils. On the other hand, cassiollin moderately inhibited the platelet aggregation induced by collagen.

Keywords

anthraquinones; anti-infla mmatory activity; antiplatelet activity; Cassia occidentalis; leguminosae; luteolins; xanthones