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8337945 
Journal Article 
Effect of drostanolone propionate on the binding of oestradiol and dihydrotestosterone by normal and malignant target tissues 
Trams, G 
1977 
13 
2 
149-153 
English 
The influence of drostanolone propionate, an anticancer agent, was tested on the binding of 17 β-oestradiol and dihydrotestosterone to specific receptor proteins in tissue of normal and neoplastic target organs. Steroid binding capacity was measured by agar gel electrophoresis of tissue extracts. Drostanolone was found to compete with androgen binding sites but not with oestrogen receptors. Therefore it is unlikely that the growth inhibitory effect of drostanolone propionate in human breast cancer is mediated through interaction with oestradiol binding proteins as suggested earlier by other authors. © 1977.