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8338758 
Meetings & Symposia 
Schwann cells and dorsal root ganglion neurons are differentially susceptible to oxidative stress induced by silicon dioxide nanoparticles 
Lai, JCK; Jaiswal, AR; Idikuda, VK; Pfau, J; Bhushan, A; Leung, SW 
2015 
Taylor and Francis Inc. 
10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference 
3 
60-63 
English 
Silicon dioxide (Si02) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as Si02 has been generally regarded as a non-toxic substance. However, the environmental safety and health impact of Si02 particles have not been elucidated. This study investigated the hypothesis that Si02 nanoparticles exert differential cytotoxic effects on DRG neurons and Schwann cells. Treatment with Si02 nanoparticles induced dose-related decreases in survival of DRG neurons and Schwann cells with Schwann cells being more susceptible. Si02 nanoparticles induced concentration-related decreases in glutathione (GSH) in Schwann cells and such decreases were related to their decreases in survival. Si02 nanoparticles also induced some decreases in GSH in DRG neurons. Expression of manganese superoxide dismutase (Mn-SOD) in Schwann cells showed concentration-related decreases when treated with Si02 nanoparticles. However, expression of Mn-SOD in DRG neurons was increased. Thus, our findings may have pathophysiological implications in the biocompatibility and health hazard of Si02 nanoparticles and may be critically relevant to toxicological studies prior to clinical trials of drugs formulated with and/or delivered employing agents containing such nanoparticles. Copyright 2015 by TechConnect. All rights reserved. 
Biocompatibility; Cytotoxicity of silicon dioxide nanoparticles; Nanotoxicity; Oxidative stress and glutathione; Schwann cells and dorsal root ganglion neurons; Silicon dioxide nanoparticles 
Technology, Institute