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8341594 
Journal Article 
Protective effects of Alnus japonica steude on hepatic injury induced by carbon tetrachloride in rats 
Kim, OK 
2003 
34 
2 
172-178 
Korean 
This study was done to investigate the protective effect of Alnus japonica Steude on hepatotoxicity in carbon tetrachloride (CCl4) intoxicated rats. Alnus japonica Steud was extracted with methanol and fractionated with hexane, chloroform, ethylacetate, butanol and water. Rats were treated with those orally once a day for 6 days. The activities of aminotransferase and γ-glutamyltranspeptidase and contents of cholesterol, TG and hepatic lipid peroxide in butanol fraction pretreated rats were significantly decreased compared to the only CCl4 treated rats but the content of glutathione was significantly increased compared to the only CCl4 treated rats. Also activities of hepatic superoxide dismutase, catalase, glutathione peroxidase in butanol fraction pretreated rats were signigicantly decreased compared to the only CCl4 treated rats. These result indicated that butanol fraction of Alnus japonica Steude showed hepatoprotective effect in carbon tetrachloride intoxicated rats. 
Alnus japonica Steude; Carbon tetrachloride; Hepatoprotective effect