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83427 
Journal Article 
Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons 
Arancio, O; Lev-Ram, V; Tsien, RY; Kandel, ER; Hawkins, RD 
1996 
Yes 
Journal of Physiology (Paris)
ISSN: 0928-4257 
90 
5-6 
321-322 
9089501 
WOS:A1996WQ67500008 
We examined long-term potentiation (LTP) at synapses between hippocampal neurons in dissociated cell culture following presynaptic, postsynaptic, or extracellular application of a nitric oxide (NO) scavenger, an inhibitor of NO synthase, and a membrane-impermeant NO donor that releases NO only upon photolysis with UV light. Our results indicate that NO is produced in the postsynaptic neuron, travels through the extracellular space, and acts directly in the presynaptic neuron to produce long-term potentiation, supporting the hypothesis that NO acts a retrograde messenger during LTP. 
long-term potentiation (LTP); nitric oxide; retrograde messenger; photolytic release