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8345731 
Journal Article 
Increase of Urinary Putrescine in 3,4-Benzopyrene Carcinogenesis and Its Inhibition by Putrescine 
Nagatsu, T; Shinpo, K; Maruta, K; Takahashi, H; Atsushl, A; Sekiya, S 
1978 
Yes 
Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445 
38 
10 
3509-3511 
English 
A significant increase in putrescine was noted in the urine of mice with experimental s.c. tumors induced by a single injection of 3,4-benzopyrene solution (2.52 mg of 3,4-benzopyrene in 0.5 ml of tricaprylin). When 10 mg of putrescine were added to the 3,4-benzopyrene solution, the development of tumors was completely inhibited and the increase of urinary putrescine in mice was suppressed simultaneously. Animal weight data of a control group receiving only putrescine indicated that the inhibitory effect of putrescine is not due to its toxicity. © 1978, American Association for Cancer Research. All rights reserved.