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8348965 
Journal Article 
The effects of prednisolone on normal pigs 
Brownlie, SE; Campbell, JG; Head, KW; Imlah, P; Mctaggart, HS; Mcvie, JG 
1978 
14 
5 
567-578 
English 
Prednisolone at doses of 0, 2, 4 and 6 mg/kg was given daily 5 days/week for 5 1 2 weeks to 4 pairs of normal Large White sibling pigs. One of each pair was then killed. Treatment caused a dose-related reduction in the size of the thymus with "overshoot" on recovery. A similar but less spectacular reduction, without "overshoot", on recovery, occurred in the lymph nodes and blood lymphocyte counts. There was also a reduction in serum total globulin levels and a complementary increase in serum albumin during treatment. Treated pigs showed a reduced contact sensitivity to DNFB during the last week of treatment. No changes attributable to treatment were observed in blood neutrophil and platelet counts nor in the red cell pictures. It is concluded that the pig falls in the "corticosteroid-resistant" group of species which includes man. © 1978. 
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