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8349904 
Journal Article 
Chalcones from Empetrum nigrum var. japonicum 
Zhao, M; Huang, SL; Wang, D; Li, J; Wang, JL; Bai, LM; Zhang, SJ 
2016 
Editorial Office of Chinese Traditional and 
47 
24 
4318-4321 
Chinese 
Objective: To study the chemical constituents from Empetrum nigrum var. japonicum. Methods: Compounds were isolated from n-hexane fraction in the industrial methanol extract from E. nigrum var. japonicum by silica gel column chromatography and HPLC. The structures of the chemical constituents were identified by analysis on their spectral data. All the isolated compounds were evaluated using relevant in vitro antitumor assay against HeLa cell lines. Results: Six compounds were isolated from n-hexane fraction in the ethanol extract from E. nigrum var. japonicum and identified as 2',5'-dihydroxy-3'-methoxy-4',6'-dimethyl-dihydrochalcone (1), 4',5'-dihydroxy-2'-methoxy-3',6'-dimethyl-dihydrochalcone (2), 2',4'-dihydroxy-dihydrochalcone (3), 2',4'-dihydroxy-chalcone (4), 2'-methoxy-4'-hydroxy-dihydrochalcone (5), and 2',4',β-trihydroxy-dihydrochalcone (6). Conclusion: Compounds 1 and 2 are new compounds, compounds 5 and 6 are obtained from the plants for the first time. Compound 6 exhibits the inhibitory activity. © 2016, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved. 
2',5'-dihydroxy-3'- methoxy-4',6'-dimethyl-dihydrochalcone; 4',5'-dihydroxy-2'-methoxy-3',6'-dimethyl-dihydrochalcone; Chalcone; Dihydrochalcone; Empetrum nigrum L. var. japonicum K. Koch; Empetrumnin; HeLa cell