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HERO ID
8359452
Reference Type
Journal Article
Title
The influence of organophosphorus compound dimethyldichlorovinyl phosphate (agonist of α7n-Acetylcholine receptor GTS-21) and epinephrine on concentration of proinflammatory cytokines in blood and mortality of mice in sepsis
Author(s)
Zabrodskll, PF; Maslyakov, VV; Gromov, MS
Year
2017
Is Peer Reviewed?
Yes
Journal
Eksperimental'naya i Klinicheskaya Farmakologiya
ISSN:
0869-2092
Volume
80
Issue
10
Page Numbers
25-28
Language
Russian
DOI
10.30906/0869-2092-2017-80-10-25-28
Abstract
Experiments on outbred albino mice showed that the effects of organophosphorus compound DDVP (dmethyldichlorovinyl phosphate, agonist of ccln-Acetylcholine receptors t3TS-21) in a single dose of 0.15 LD50 (5 mg/kg daily for 4 days) and epinephrine in a dose of 0.3 mg/kg (s.c. once daily for 4 days) in 4 h after sepsis modeling (intraperitoneal injexctioo of 24-h B. coli culture 2.5 l0 microbial bodies) significantly reduced the mortality of mice within 4 and 24 h and the blood levels of TNT-cs, 11.-l 9 and IL-6 as compared to the parameters in sepsis without the use of drugs. The DDVP-induced decrease of mortality from sepsis in mice is associated with a decrease in the concentration of blood-α, IL-Iβ and IL-6 and is due both to the implementation of the cholinergic anti-iifflammatory pathways, particularly with the activation of ce7n-Acetylcholine receptors and excitation of the sympathetic nervous system.
Keywords
Epinephrine; Organophosphorus compounds; Proinflammatory cytokines; α7n-Acetylcholine receptor
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