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8361782 
Journal Article 
AI adenosine receptor antagonism improves glucose tolerance in Zucker rats 
Baiyang, XU; Berkich, DA; Grist, GH; Lanoue, KF 
1998 
Yes 
American Journal of Physiology
ISSN: 0002-9513
EISSN: 2163-5773 
274 
2 PART 1 
E271-E279 
English 
The A1 adeno-sine receptor (Alar) antagonist l,3-dipropyl-8-(p-acrylic)phenylxanthine (BW-1433) was administered to lean and obese Zucker rats to probe the influence of endogenously activated Alars on whole body energy metabolism. The drug, induced a transient increase in lipolysis as indicated by a rise in serum glycerol in obese rats. The disappearance of the response by day 7 of chronic studies was accompanied by an increase in Alar numbers. Glucose tolerance tests were administered to rats treated with BW-1433. Peak serum insulin levels and areas under glucose curves (AUGs) were 34 and 41% lower in treated obese animals than in controls, respectively, and 19 and 39% lower in lean animals. With chronic administration (6 wk), AUGs decreased 47 and 33% in obese and lean animals, respectively. There was no effect of BW-1433 in either lean or obese rats on weight gain or percent body fat. Thus the major sustained influence of whole body Alar antagonism in both lean and obese animals was an increase in whole body glucose tolerance at lower levels of insulin. " obesity; lipolysis; insulin sensitivity Copyright ©1998 the American Physiological Society.