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8380812 
Journal Article 
Serum chromium, manganese, zinc and hemoglobin A1c % in Sudanese with type 2 diabetes 
Elabid, BEH; Ahmed, SM 
2014 
1 
Life Science Journal
ISSN: 1097-8135 
11 
9 
320-322 
English 
There is accumulating evidence that the metabolism of several trace elements is altered in diabetes mellitus, and these elements might have specific roles in the pathogenesis and progress of this disease. The objective of this study is to compare the serum levels of Chromium, Manganese and Zinc in Sudanese with type 2 Diabetes with that of non-diabetic healthy controls and to assess the relationship of these elements with the glycemic status and duration of diabetes. A case-control study was conducted at two diabetes centers in Khartoum state, Sudan, during the period from March to December 2013. A total of 200 diabetic patients and 100 healthy controls were enrolled in this study. Both groups were matched for age and gender. The serum levels of Chromium, Manganese and Zinc were measured using atomic absorption spectrophotometry technique. SPSS was used for analysis of data. The means of the serum levels of Chromium, Manganese and Zinc were significantly reduced when compared with the control group (P < 0.05).The serum levels of Chromium, Manganese and Zinc in the diabetic group, all had significant inverse moderate correlations with the duration of diabetes and Hemoglobin A1c%(P < 0.05), except serum Manganese which had insignificant inverse moderate correlation with the duration of diabetes(P > 0.05). In conclusion, The results showed significantly reduced serum levels of Chromium, Manganese and Zinc. The three trace elements had inverse moderate correlations with both; the duration of Diabetes and Hemoglobin A1c%. 
Trace elements; Type 2 diabetes; Hb A1c