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8381915 
Journal Article 
Iron-catalyzed benzamide formation. Application to the synthesis of moclobemide 
Bantreil, X; Kanfar, N; Gehin, N; Golliard, E; Ohlmann, P; Martinez, J; Lamaty, F 
2014 
1 
Tetrahedron
ISSN: 0040-4020 
Elsevier Ltd 
70 
34 
5093-5099 
English 
A convenient and user-friendly method to yield benzamides from primary and secondary amines and various benzylic alcohols in the presence of a cheap iron salt (FeCl2·4H2O) and tert-butylhydroperoxide (70% in water) as a stoichiometric oxidant is described. Control experiments indicated that this reaction might involve radical species. This method proved to be general, generating a family of 30 benzamides and was applied to the preparative synthesis of anti-anxiety drug moclobemide. © 2014 Elsevier Ltd. All rights reserved. 
Amides; Green chemistry; Homogeneous catalysis; Iron; Oxidation