US EPA

8383657 

Journal Article 

Formulation and evaluation of permeation kinetics of doxycyclin gel 

Bano, S; Shah, SNH; Ubaid, M; Ismail, T; Khan, SA; Nawaz, A; Murtaza, G 

2015 

0 

Latin American Journal of Pharmacy
ISSN: 0326-2383 

Colegio de Farmaceuticos de la Provincia de Buenos Aires 

34 

10 

1968-1974 

English 

Propylene glycol (PG) and polyethylene glycol (PEG) were used as permeation enhancers to enhance percutaneous absorption of doxycycline tri-hydrate, an antibiotic which is hydrophilic in nature. Various hydroalcoholic gels of doxycycline were prepared containing PG and PEG in varying proportions. The permeation experiments were performed in vitro through silicon membrane in modified Franz diffusion cell at 37 ± 1 ºC. The physical characteristics like pH, viscosity and spreadability of all formulated gels were tested. Permeation kinetic parameters like flux, diffusion coefficient, permeation coefficient and enhancement ratios were calculated. Ex vivo Draize’s skin irritation test and stability studies of optimized Gel G5 were performed. In all hydroalcoholic gels, doxycycline tri-hydrate was released and permeated through silicone membrane; and consequently, greater influence observed at equal levels of PG and PEG. Among all gel formulations, G5 presented the highest flux with minimum lag time. The optimized G5 showed no irritation to skin and was found physicochemically stable. In conclusion, the combination of PG and PEG can be successfully utilized as permeation enhancers for transdermal delivery of doxycycline. © 2015, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved. 

Doxycycline gel; Permeation enhancers; Permeation kinetics; Physicochemical stability