Health & Environmental Research Online (HERO)


Print Feedback Export to File
8394267 
Journal Article 
13β,14β‐dihydroxy‐13α‐isopropylabietic acid, an elicitor of contact allergy 
Khan, L; Saeed, MA 
1994 
Yes 
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 
83 
909-910 
English 
Abietic acid isolated from colophony (W.W. grade) was selectively oxidized in the presence of KMnO4, into 13β, 14β‐dihydroxy‐14α‐isopropylabietic acid. The structure of the compound was elucidated using UV, IR, and NMR spectroscopy. Epicutaneous application of the dihydroxy acid to colophony‐sensitized guinea pigs suggested the compound as an elicitor of contact allergy that had not been tested before in contact‐sensitization reactions. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company