Formation and persistence of arylamine DNA adducts in vivo | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8394378

Reference Type

Journal Article

Title

Formation and persistence of arylamine DNA adducts in vivo

Author(s)

Beland, FA; Kadlubar, FF

Year

1985

Is Peer Reviewed?

Yes

Journal

Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924

Volume

VOL. 62

Page Numbers

19-30

Language

English

PMID

4085422

DOI

10.1289/ehp.856219

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022273489&doi=10.1289%2fehp.856219&partnerID=40&md5=ded02a416910cdbcb14f54f6ca4b03fe
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Abstract

Aromatic amines are urinary bladder carcinogens in man and induce tumors at a number of sites in experimental animals including the liver, mammary gland, intestine, and bladder. In this review, the particular pathways involved in the metabolic activation of aromatic amines are considered as well as the specific DNA adducts formed in target and nontarget tissue. Particular emphasis is placed on the following compounds: 1-naphthylamine, 2-naphthylamine, 4-aminobiphenyl, 4-acetylaminobiphenyl, 4-acetylamino-4'-fluorobiphenyl, 3,2'-dimethyl-4-aminobiphenyl, 2-acetylaminofluorene, benzidine, N-methyl-4-aminoazobenzene, 4-aminoazobenzene, and 2-acetylaminophenanthrene.

Keywords

Environment Abstracts; LITERATURE SURVEYS; AROMATIC HYDROCARBONS; PATHOLOGY, ANIMALLABORATORY; CARCINOGENIC AGENTS; ENA 07:General