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8400935 
Journal Article 
Drug toxicity and adverse drug reactions in children - A brief historical review 
Choonara, I; Rieder, MJ 
2002 
5 
1 
12-18 
English 
Drug toxicity in association with adverse drug reactions is common in hospitalised children. The toxicity of medicines in children is different to that seen in adults. There are also differences between different age groups of paediatric patients with neonates being generally at greater risk for experiencing a drug-associated adverse event. The major examples of drug toxicity that have occurred in paediatric patients are reviewed ranging from percutaneous toxicity over 100 years ago to formulation errors and toxicity associated with normal, developmental alterations in drug metabolism. The need to learn from previous cases of drug toxicity to prevent future cases is paramount. 
Children; Drug metabolism; Drug toxicity